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What is Ovaprim?
Ovaprim is a two-part drug consisting of 1) a shorter, synthetic version of GnRH and 2) domperidone. Ovaprim is marketed ready to inject in a liquid form.
In the ornamental fish industry, Ovaprim is used as a spawning aid to induce ovulation (release of mature oocytes/eggs) and spermiation (release of milt/sperm) in mature, properly conditioned brood-fish. Ovaprim is especially useful for species for which natural spawning in captivity is difficult to induce.

NOTE: Use of Ovaprim does not guarantee successful fertilization, development, and hatch of fry. Overall good husbandry and hatchery management, including good genetics, proper nutrition, environment (including water quality), substrates, social structure, and other factors will affect egg and milt quality, egg hatch, and fry survival.
How does Ovaprim work?
For some ornamental species, determining which natural environmental cues will lead to ovulation and spermiation has been difficult. Ovaprim's synthetic GnRH closely resembles that of naturally occurring GnRHs and, in many species, is actually more potent (Figure 1b). When injected into the body cavity (coelom or abdomen) or muscle of receptive, mature, conditioned fish, the synthetic GnRH travels from the injection site through the blood to activation sites in the pituitary gland. Ovaprim initiates the reproductive cascade and eliminates the need for a natural trigger. Domperidone, the other active component of Ovaprim, helps block the inhibitory effects of dopamine. Domperidone, therefore, is very important for induced spawning of species for which the reproductive cascade would be stopped because of stressors that lead to dopamine release, because dopamine will block GnRH activity.