Galanthamine Hydrobromide
Introduction
Galanthamine is natural extracted from lycoris radiate,is a tertiary alkaloid derived from snow drop and closely related species. It acts as a reversible competitive acetylcholinesterase (ACHE) inhibitor, while acts weaker on butyrylcholinesterse(BuChE).it is used in the treatment of disorders of the central nerbous system and may be used as an antidote to nonpolarizing muscle relaxants.Galanthamine hydrobromide is a white to almost white powder; sparingly soluble in water; insoluble chloroform,ether and alcohol.
Specifications of Galanthamine Hydrobromide
ANALYSIS | SPECIFICATION | RESULTS |
Appearance | White to off-white crystalline powder | Complies |
Odor | Characteristic | Complies |
Assay (HPLC) | ≥98.0% | 98.45% |
Sieve analysis | 100% pass 80 mesh | Complies |
Loss on Drying | ≤5.0% | 3.15% |
Ash | ≤5.0% | 2.15% |
Heavy Metal |
|
|
Pb | <2ppm | Complies |
As | <2ppm | Complies |
Hg | <2ppm | Complies |
Residual Solvent | Eur.Pharm | Complies |
Microbiology |
| |
Total Plate Count | <1000cfu/g | Complies |
Yeast & Moulds | <100cfu/g | Complies |
E.Coli | Negative | Complies |
Salmonella | Negative | Complies |
Salmonella | Negative | Complies |
Function and Usage
Galanthamine Hydrobromide is the anti-cholinesterase, weak effect.
It has strong effect to the central nervous system through the blood brain barrier.
It mainly cures the infantile paralysis sequelae, sweeny and myasthenia gravis
pseudoparalytica, etc. It also can be applied to puerilism, posttraumatic apoplexy,
polyneuritis and radiculitis.
Clinic function: mainly used in myasthenia gravis, poliovirus quiescent stage and
sequela, also in polyneuritis, funiculitis and sensorimotor barrier caused by nervous
system disease or traumatism. It’s major used in Alzheimer's disease, has the principal
function for dement and dysmnesia caused by organic brain damage.
Storage and Shelf Life
Storage | Store in a well-closed container away from moisture |
Shelf Life | 2 years if sealed and store away from direct sun light. |
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