Basic Info

Product name	Dapoxetine Hydrochloride
Alias	D-dapoxinetine HCL;D-(+),N-dimethyl-3-(naphthalen-1-yloxy)-1-phenyl-propan-1-amine hydrochloride
CAS No.	129938-20-1
M.F.	C21H24ClNO
M.W.	341.8744
Assay	99%
Appearance	White crystalline powder

Description
Dapoxetine hydrochloride,a fast-acting serotonin reuptake transporter inhibitor,is generally prescribed for the treatment and management of premature ejaculation and erectile dysfunction in adult male.Due to the lack of specific approval treatment for PE in the US and some other countries,other SSRIs such as Fluoxetine,Paroxetine,Sertraline,Fluvoxamine and Citalopram have been used as clinical drugs to treat PE.Waldinger's meta analysis shows that the use of these conventional antidepressants increasing IELT about 2-9 time in comparison of three to eight times when Dapoxetine is used.However,these SSRIs must be taken daily in order to achieve meaningful efficacy,and the long half-life increases the risk of the drug accumulation and as a consequence,an increasing adverse effects such as decreasing sexual libido and causing erectile dysfunction.Dapoxetine,on the other hand,is a fast-acting SSRI.It is rapidly absorbed and eliminated from the body within a few hours.This favorable pharmacokinetics minimizes the risk of the drug's accumulation in the body,and therefore reducing side effects.

Dapoxetine hydrochloride is a drug that is used to treat premature ejaculation in men.It is available by prescription and is taken orally,prior to sexual intercourse.The drug belongs to the class called serotonin reuptake inhibitors (SSRIs),which have mainly been used to treat depression.

Sexual dysfunction,including premature ejaculation,is an extremely common condition worldwide.The cause of premature ejaculation has not been fully elucidated,but may include both psychological and physiological factors.Premature ejaculation refers to a short ejaculation time,which can affect the satisfaction of both partners during sexual intercourse.

To treat premature ejaculation,both psychological and physiological factors need to be managed.From a pharmacological point-of-view,to treat the physiological aspect of premature ejaculation,dapoxetine hydrochloride is one of the first oral drugs to be made available.Psychological treatment may be given concomitantly,as the condition is multifactorial.

One of the possible adverse effects reported with SSRIs when used to treat depression is delayed ejaculation.This reported adverse effect led to the studies of dapoxetine hydrochloride,using the effect therapeutically.It is thought that serotonin may be involved in the inhibition of ejaculation.By blocking the serotonin reuptake in men suffering from premature ejaculation,the time to ejaculation may be prolonged.

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