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Basic Info
Descript ion
Dutasteride (trademark name Avodart) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).Used for benign prostatic hyperplasia;however,it increases the risk of erectile dysfunction and decreased sexual desire.
Dutasteride useful for the symptoms of benign prostatic hyperplasia (BPH);colloquially known as an "enlarged prostate".In those who are being regularly screened 5-alpha-reductase inhibitor (finasteride and dutasteride) reduce the overall risk of being diagnosed with prostate cancer however there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases.
Application
Dutasteride,along with Finasteride is a 5-alpha-Reductase inhibitor which are a group of drugs with anti-androgenic properties which inhibit the conversion of testosterone into dihydrotestosterone (DHT).This is the same chemical found in Proscar and Propecia and is used in the treatment hyperplasia and androgenic alopecia.Because these drugs reduce levels of dihydrotestosterone (DHT) they are used to prevent and treat hairloss.It is most commonly used to treat enlarged prostate glands.
While the potential for positive,negative or neutral changes to the potential risk of developing prostate cancer with dutasteride has not been established,evidence has suggested it may temporarily reduce the growth and prevalence of benign prostate tumors,but could also mask the early detection of prostate cancer.
The primary area for concern is for patients who may develop prostate cancer whilst taking dutasteride for benign prostatic hyperplasia,which in turn could delay diagnosis and early treatment of the prostate cancer,thereby potentially increasing the risk of these patients developing high-grade prostate cancer.
COA
Other Anti-Estrogens&PCT Powders
Tamoxifen Citrate CAS 54965-24-1
Raloxifene Hydrochloride CAS 82640-04-8
Clomifene citrate(Clomid) CAS 50-41-9
M-esterolone(Proviron) CAS 1424-00-6
L-etrozole(Femara) CAS 112809-51-5
A-nastrozole(Arimidex) CAS 120511-73-1
E-xemestane(Aromasin) CAS 107868-30-4
F-ormestane(Lentaron) CAS 566-48-3
Toremifene Citrate CAS 89778-27-8
Finasteride(Proscar,Propecia) CAS 98319-26-7
Dutasteride(Avodart) CAS 164656-23-9
T-estolactone(Teslac) CAS 968-93-4
| product Name | Dutasteride |
| Synonyms | (5alpha,17beta)-n-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide;Avodart |
| CAS Registry Number | 164656-23-9 |
| Assays | 99% |
| Molecular Formula | C27H30F6N2O2 |
| Molecular Weight | 528.53 |
| Appearance | White or white crystalline powder |
| Usage | Pharmaceutical Intermediates |
De
Dutasteride (trademark name Avodart) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).Used for benign prostatic hyperplasia;however,it increases the risk of erectile dysfunction and decreased sexual desire.
Dutasteride useful for the symptoms of benign prostatic hyperplasia (BPH);colloquially known as an "enlarged prostate".In those who are being regularly screened 5-alpha-reductase inhibitor (finasteride and dutasteride) reduce the overall risk of being diagnosed with prostate cancer however there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases.
Application
Dutasteride,along with Finasteride is a 5-alpha-Reductase inhibitor which are a group of drugs with anti-androgenic properties which inhibit the conversion of testosterone into dihydrotestosterone (DHT).This is the same chemical found in Proscar and Propecia and is used in the treatment hyperplasia and androgenic alopecia.Because these drugs reduce levels of dihydrotestosterone (DHT) they are used to prevent and treat hairloss.It is most commonly used to treat enlarged prostate glands.
While the potential for positive,negative or neutral changes to the potential risk of developing prostate cancer with dutasteride has not been established,evidence has suggested it may temporarily reduce the growth and prevalence of benign prostate tumors,but could also mask the early detection of prostate cancer.
The primary area for concern is for patients who may develop prostate cancer whilst taking dutasteride for benign prostatic hyperplasia,which in turn could delay diagnosis and early treatment of the prostate cancer,thereby potentially increasing the risk of these patients developing high-grade prostate cancer.
COA
| Test Items | Specification | Test Results |
| De |
White or almost white powder | Complies |
| Identification | Meet the requirements | Complies |
| Loss on drying | ≤0.5% | 0.2% |
| Melting range | 246ºC~252ºC | 246ºC~248ºC |
| Heavy |
≤20ppm | Complies |
| Residue on ignition | ≤0.1% | Complies |
| Related substances | Biggest Impurities≤0.5% | 0.36% |
| Total Impurity≤1.0% | 0.7% | |
| Assay | 97.0%~103.0% | 99.3% |
| Conclusion | Complies with In-house Standard | |
Other Anti-Estrogens&PCT Powders
Tamoxifen Citrate CAS 54965-24-1
Raloxifene Hydrochloride CAS 82640-04-8
Clomifene citrate(Clomid) CAS 50-41-9
M-esterolone(Proviron) CAS 1424-00-6
L-etrozole(Femara) CAS 112809-51-5
A-nastrozole(Arimidex) CAS 120511-73-1
E-xemestane(Aromasin) CAS 107868-30-4
F-ormestane(Lentaron) CAS 566-48-3
Toremifene Citrate CAS 89778-27-8
Finasteride(Proscar,Propecia) CAS 98319-26-7
Dutasteride(Avodart) CAS 164656-23-9
T-estolactone(Teslac) CAS 968-93-4
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